Майкл Стюарт Браун: биография

The LDL receptor gene: a mosaic of exons shared with different proteins. Science. 1985 May 17; 228 (4701) :815-22.

Cassette of eight exons shared by genes for LDL receptor and EGF precursor. Science. 1985 May 17; 228 (4701) :893-895

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. Cell. 1985 May; 41 (1) :249-58.

Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain. Cell. 1985 Jul; 41 (3) :735-43.

5 'end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription. Cell. 1985 Aug; 42 (1) :203-12.

Scavenger cell receptor shared. Nature. 1985 Aug 22-28; 316 (6030) :680-1.

A receptor-mediated pathway for cholesterol homeostasis. Science. 1986 Apr 4; 232 (4746) :34-47.

The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors Cell. 1986 Apr 11; 45 (1) :15-24.

Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science. 1986 Jun 6; 232 (4755) :1230-7.

Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia. Cell. 1987 Mar 13; 48 (5) :827-35.

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. Cell. 1987 Mar 27; 48 (6) :1061-9.

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature. 1987 Apr 23-29; 326 (6115) :760-765

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science. 1988 Mar 11; 239 (4845) :1277-81.

Inhibition of purified p21ras farnesyl: protein transferase by Cys-AAX tetrapeptides. Cell. 1990 Jul 13; 62 (1) :81-8.

Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors. Science. 1990 Nov 30; 250 (4985) :1273-5

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. Тисяча дев'ятсот дев'яносто-один May 3; 65 (3) :429-34.

CDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1. Cell. 1991 Jul 26; 66 (2) :327-34.

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product. Cell. 1992 Sep 18; 70 (6) :1049-57.

Koch's postulates for cholesterol. Cell. 1992 Oct 16; 71 (2) :187-8.

cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. Cell. 1993 Jun 18; 73 (6) :1091-9

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell. 1993 Oct 8; 75 (1) :187-97.

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell. 1994 Mar 11; 76 (5) :865-73.

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 1994 Apr 8; 77 (1) :53-62

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell. 1996 Jun 28; 85 (7) :1037-46

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell. 1996 Nov 1; 87 (3) :415-26.

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1 997 May 2; 89 (3) :331-40.

Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell. 1999 Dec 23; 99 (7) :703-12.

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell. 2000 Feb 18; 100 (4) :391-8.

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell. 2000 Aug 4; 102 (3) :315-23.

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell. 2002 Aug 23; 110 (4) :489-500.

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